Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1104020 | 0.74 | POLB (0.40) | POLBALDH1A1KMT2AABCC4MAPT | |
| SCHEMBL3590647 | 0.74 | POLB (0.40) | POLBALDH1A1KMT2AABCC4MAPT | |
| SCHEMBL10303857 | 0.73 | POLB (0.43) | POLBALDH1A1KMT2AABCC4MAPT | |
| SCHEMBL14850987 | 0.71 | POLB (0.35) | POLBALDH1A1KMT2ATAAR1ABCC4 | |
| SCHEMBL17121284 | 0.68 | POLB (0.41) | POLBALDH1A1KMT2AABCC4MAPT | |
| SCHEMBL30449957 | 0.68 | MAPT (0.54) | ALDH1A1ABCC4MAPTTSHRLMNA | |
| SCHEMBL1469535 | 0.68 | MAPT (0.54) | ALDH1A1ABCC4MAPTTSHRLMNA | |
| SCHEMBL4021318 | 0.68 | MAPT (0.54) | ALDH1A1ABCC4MAPTTSHRLMNA | |
| SCHEMBL19215358 | 0.67 | ALDH1A1 (0.42) | POLBALDH1A1KMT2AABCC4MAPT | |
| SCHEMBL14483836 | 0.66 | POLB (0.97) | POLBALDH1A1KMT2AGAATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349869-B2 | Macrocylic inhibitors of hepatitis C virus | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2013-01-08 | — | — | US | disclosed |