Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | VCP | P55072 | 4/20 | 0.45 |
| ▸ | FLT1 | P17948 | 6/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14045610 | 0.83 | ROCK2 (0.52) | ROCK2SYKEGFRVCPFLT1 | |
| SCHEMBL849257 | 0.82 | SYK (0.62) | ROCK2SYKEGFRKDRCDK1 | |
| SCHEMBL879559 | 0.81 | ROCK2 (0.52) | ROCK2SYKEGFRVCPFLT1 | |
| SCHEMBL14850419 | 0.77 | SYK (0.49) | ROCK2SYKEGFRVCPFLT1 | |
| SCHEMBL14548767 | 0.77 | IGF1R (0.44) | ROCK2EGFRKDRMAPKAPK2CDK1 | |
| SCHEMBL4875518 | 0.77 | SYK (0.56) | ROCK2SYKEGFRKDRCDK1 | |
| SCHEMBL3459130 | 0.77 | AURKA (0.61) | ROCK2SYKEGFRKDRCDK1 | |
| SCHEMBL4873820 | 0.76 | SYK (0.48) | ROCK2SYKEGFRVCPFLT1 | |
| SCHEMBL4882766 | 0.76 | KDR (0.66) | ROCK2SYKEGFRKDRCDK1 | |
| SCHEMBL14024356 | 0.76 | KDR (0.66) | ROCK2SYKEGFRKDRCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349859-B2 | Pyrimidine derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2013-01-08 | — | — | US | disclosed |