Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 3/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.45 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.45 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12106522 | 0.86 | TTR (0.58) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| SCHEMBL14642034 | 0.83 | PTGS2 (0.48) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| SCHEMBL3332430 | 0.75 | TTR (0.61) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| SCHEMBL5605812 | 0.75 | TTR (0.61) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| SCHEMBL27637963 | 0.74 | TTR (0.60) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| SCHEMBL4252659 | 0.74 | TTR (0.60) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| SCHEMBL5605274 | 0.74 | TTR (0.60) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| SCHEMBL8646851 | 0.73 | TTR (0.65) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| SCHEMBL13240140 | 0.73 | TTR (0.56) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| SCHEMBL24042694 | 0.72 | TTR (0.64) | PTGS2PTGS1CYP2C9CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357723-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-22 | — | — | US | disclosed |
| US-8349901-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-08 | — | — | US | disclosed |