Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.48 |
| ▸ | BRD4 | O60885 | 9/20 | 0.46 |
| ▸ | BRD2 | P25440 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4270915 | 0.76 | SRC (0.63) | SRCBRD4BRD2ERN1BRD3 | |
| SCHEMBL15095284 | 0.75 | SRC (0.40) | SRC | |
| SCHEMBL17698634 | 0.69 | BRD4 (0.63) | BRD4BRD2CREBBPERN1BRD3 | |
| SCHEMBL16132522 | 0.67 | BRD4 (0.54) | BRD4BRD2CREBBPERN1BRD3 | |
| SCHEMBL15782904 | 0.66 | BRD4 (0.62) | BRD4BRD2CREBBPERN1BRD3 | |
| SCHEMBL16132488 | 0.66 | FTO (0.49) | BRD4BRD2ERN1BRD3 | |
| SCHEMBL20362718 | 0.66 | BRD4 (0.49) | BRD4BRD2CREBBPERN1BRD3 | |
| SCHEMBL4272365 | 0.66 | SRC (1.00) | SRCBRD4BRD2BRD3 | |
| SCHEMBL9932071 | 0.66 | BRD4 (0.57) | BRD4BRD2CREBBPERN1BRD3 | |
| SCHEMBL18635203 | 0.65 | BRD4 (0.51) | BRD4BRD2CREBBPERN1BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809614-B1 | BENZOTRIAZINE INHIBITORS OF KINASES | TARGEGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |
| EP-2543376-A1 | Benzotriazine inhibitors of kinases | Targegen, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |