Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 20/20 | 1.00 |
| ▸ | GUCY1B1 | Q02153 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447914 | 0.90 | GUCY1A1 (0.82) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL2450778 | 0.90 | GUCY1A1 (0.86) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL14549833 | 0.89 | GUCY1A1 (0.80) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL14549781 | 0.89 | GUCY1A1 (1.00) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL14549800 | 0.85 | GUCY1A1 (1.00) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL2454275 | 0.85 | GUCY1A1 (0.73) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL14549782 | 0.84 | GUCY1A1 (0.79) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL14549837 | 0.83 | GUCY1A1 (0.76) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL2445889 | 0.83 | GUCY1A1 (0.71) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL12323241 | 0.82 | GUCY1A1 (0.73) | GUCY1A1GUCY1B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284301-B2 | Soluble guanylate cyclase activators | MERCK SHARP & DOHME CORP. (US) | 2016-03-15 | — | — | US | disclosed |
| US-20130012511-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME LLC | 2013-01-10 | — | — | US | disclosed |
| US-20130012511-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME LLC | 2013-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012511-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | PDE3B, PDE3A, GUCY1B1 | GUCY1A1 5/4885GUCY1B1 3/4885KCNH2 666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.