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Sugi Predict / Targets / GUCY1B1

GUCY1B1

Guanylate cyclase soluble subunit beta-1 (GCS · Q02153 · GUCY1B1 on Sugi Atlas →

23,728 patent compounds predicted against GUCY1B1, 13,234 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Hydrochloric Acid Hydrochloric Acid (SCHEMBL253278) 0.85 20/20
SCHEMBL2447914 SCHEMBL2447914 0.82 20/20
SCHEMBL250991 SCHEMBL250991 0.79 20/20
SCHEMBL252290 SCHEMBL252290 0.78 20/20
SCHEMBL2445889 SCHEMBL2445889 0.71 20/20
SCHEMBL2441721 SCHEMBL2441721 0.70 20/20
SCHEMBL2436846 SCHEMBL2436846 0.69 20/20
SCHEMBL253803 SCHEMBL253803 0.67 20/20
SCHEMBL2441717 SCHEMBL2441717 0.66 20/20
SCHEMBL253844 SCHEMBL253844 0.66 20/20
SCHEMBL254496 SCHEMBL254496 0.65 20/20
SCHEMBL2445297 SCHEMBL2445297 0.65 20/20
SCHEMBL2445626 SCHEMBL2445626 0.65 20/20
SCHEMBL2445293 SCHEMBL2445293 0.64 20/20
SCHEMBL252384 SCHEMBL252384 0.59 20/20
SCHEMBL211585 SCHEMBL211585 0.59 20/20
SCHEMBL253217 SCHEMBL253217 0.59 20/20
SCHEMBL1784657 SCHEMBL1784657 0.56 20/20
SCHEMBL1784660 SCHEMBL1784660 0.56 20/20
SCHEMBL251237 SCHEMBL251237 0.54 20/20

Clinical trials — most relevant to GUCY1B1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Switching of Sildenafil to Riociguat in CTEPH Patients PHASE4RECRUITING
Bosentan in Treatment of Pulmonary Arterial Hypertension PHASE4COMPLETED
The Effect of Vericiguat on Peripheral Vascular Function, Patient Health Status and Inflammation PHASE4COMPLETED
Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes PHASE4COMPLETED
Methylene Blue and Microcirculation in Septic Shock PHASE3UNKNOWN
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia PHASE2/PHASE3UNKNOWN
Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm PHASE2WITHDRAWN
Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease PHASE2COMPLETED
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE PHASE2UNKNOWN
Tadalafil for Pulmonary Hypertension Due to Chronic Lung Disease PHASE2COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
The STRETCH Study: Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic Hypertension PHASE2COMPLETED
STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH PHASE2COMPLETED
Effects of Nitrite on Blood Vessel Dilation in Normal Volunteers PHASE2COMPLETED
Vascular Effects of Endothelium-Derived Versus Hemoglobin-Transported Nitric Oxide in Healthy Subjects PHASE1COMPLETED
Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers PHASE1COMPLETED
Vitamin D Versus Sildenafil Citrate in Fetal Growth Restriction PHASE1COMPLETED
: Vascular Function in Health and Disease PHASE1RECRUITING
Trial of IW-1701 (A Stimulator of Soluble Guanylate Cyclase (sGC)) in Healthy Volunteers PHASE1COMPLETED
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses PHASE1COMPLETED
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL EARLY_PHASE1UNKNOWN
The Effect of Polymorphism of the GUCY1A3 rs7692387 Gene on Cardiovascular Events After Coronary Artery Bypass Grafting. nanUNKNOWN
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia nanRECRUITING
Screening for Alpha Thalassemia in Healthy Volunteers nanACTIVE_NOT_RECRUITING
OrthoCor Advanced Trial for Knee Osteoarthritis nanCOMPLETED
The Genetic Study of Primary Angle-Closure Glaucoma nanUNKNOWN
Analysis of Genes That Predispose People to Develop High Blood Pressure nanCOMPLETED
Genetic Markers of CHD Risk in Men and Women nanCOMPLETED
Sildenafil Citrate Added to Low Molecular Weight Heparin and Low Dose Aspirin in High-risk Pregnancy nanWITHDRAWN

Related proteins — ESM-2 sequence neighbours (a GUCY1B1 binder may also engage these)

ProteinNameSimilarity
P20595 — 1.000 P20595 →
Q4ZHR9 — 1.000 Q4ZHR9 →
P16068 — 1.000 P16068 →
O54865 — 1.000 O54865 →
Q8WTW4 — 0.950 Q8WTW4 →
GLS Glutaminase kidney isoform, mitochondrial 0.949 landscape →
Q5NVN7 — 0.949 Q5NVN7 →
Q5E9U9 — 0.948 Q5E9U9 →
O89050 — 0.948 O89050 →
DHX9 ATP-dependent RNA helicase A 0.948 landscape →
Q9WUE4 — 0.947 Q9WUE4 →
SAE1 SUMO-activating enzyme subunit 1 0.946 landscape →
Q9UL63 — 0.946 Q9UL63 →
P13264 — 0.946 P13264 →
Q9NVE7 — 0.946 Q9NVE7 →
D3Z7P3 — 0.946 D3Z7P3 →
Q5R874 — 0.945 Q5R874 →
Q4R4U1 — 0.945 Q4R4U1 →
Q5R5F8 — 0.945 Q5R5F8 →
Q99PV3 — 0.944 Q99PV3 →
Q9QXK7 — 0.944 Q9QXK7 →
TRPC7 Short transient receptor potential channel 7 0.943 landscape →
P38024 — 0.943 P38024 →
Q5M887 — 0.942 Q5M887 →
Q91YD4 — 0.942 Q91YD4 →
Q9PW38 — 0.942 Q9PW38 →
Q6AXQ0 — 0.942 Q6AXQ0 →
O70133 — 0.942 O70133 →
O43913 — 0.941 O43913 →
Q8BUV3 — 0.941 Q8BUV3 →