Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8957520 | 0.87 | CSNK2A1 (0.53) | CSNK2A1HTR1DTBXAS1GPR84HTR2A | |
| SCHEMBL6029337 | 0.81 | CSNK2A1 (0.53) | CSNK2A1TBXAS1GPR84 | |
| SCHEMBL13262495 | 0.80 | MCL1 (0.48) | MCL1HTR1DNPC1LMNAMAPK1 | |
| SCHEMBL11924849 | 0.77 | CSNK2A1 (0.54) | CSNK2A1HTR1DNPC1GPR84HTR2A | |
| SCHEMBL18708142 | 0.76 | CSNK2A1 (0.57) | CSNK2A1GPR84HTR2AHTR2CHTR2B | |
| SCHEMBL15074715 | 0.76 | HTR2A (0.59) | CSNK2A1HTR1DGPR84HTR2AHTR2C | |
| SCHEMBL9001726 | 0.76 | HTR1D (0.40) | HTR1DNPC1HTR2AHTR1AHTR1B | |
| SCHEMBL9006989 | 0.75 | CFTR (0.38) | MCL1HTR1DNPC1LMNAMAPK1 | |
| SCHEMBL273402 | 0.73 | CSNK2A1 (0.57) | CSNK2A1HTR1DGPR84HTR2AHTR1B | |
| SCHEMBL29354243 | 0.73 | CSNK2A1 (0.77) | CSNK2A1GPR84HTR2AHTR1ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130011923-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-10 | — | — | US | disclosed |