Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273402 | 0.80 | CSNK2A1 (0.57) | CSNK2A1GPR84HTR2AHTR2CMPO | |
| SCHEMBL6029334 | 0.80 | CSNK2A1 (0.77) | CSNK2A1GPR84SLC6A4HTR2AHTR2C | |
| SCHEMBL29354243 | 0.80 | CSNK2A1 (0.77) | CSNK2A1GPR84SLC6A4HTR2AHTR2C | |
| SCHEMBL1242939 | 0.80 | GPR84 (0.67) | CSNK2A1GPR84SLC6A4HTR2AHTR2C | |
| SCHEMBL15074715 | 0.80 | HTR2A (0.59) | CSNK2A1GPR84HTR2AHTR2CHTR2B | |
| SCHEMBL29352833 | 0.80 | GPR84 (0.67) | CSNK2A1GPR84SLC6A4HTR2AHTR2C | |
| SCHEMBL6198753 | 0.80 | GPR84 (0.67) | CSNK2A1GPR84SLC6A4HTR2A | |
| SCHEMBL14964102 | 0.78 | CSNK2A1 (0.54) | CSNK2A1GPR84SLC6A4HTR2AHTR2C | |
| SCHEMBL11924849 | 0.78 | CSNK2A1 (0.54) | CSNK2A1GPR84HTR2AHTR2CHTR2B | |
| SCHEMBL20432631 | 0.77 | SLC6A4 (0.45) | GPR84SLC6A4HTR2AHTR2CCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216787-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2502911-B1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2017-04-05 | — | — | EP | disclosed |