Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | FDPS | P14324 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.60 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.60 |
| ▸ | TACR2 | P21452 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699064 | 0.88 | ALDH1A1 (0.66) | ALDH1A1MAPTMEN1KMT2AFDPS | |
| SCHEMBL12517074 | 0.88 | ALDH1A1 (0.66) | ALDH1A1MAPTMEN1KMT2AFDPS | |
| SCHEMBL7784719 | 0.88 | PDCD1 (0.74) | ALDH1A1MAPTMEN1KMT2AFDPS | |
| SCHEMBL24723792 | 0.87 | ALDH1A1 (0.68) | ALDH1A1MAPTMEN1KMT2AFDPS | |
| SCHEMBL413085 | 0.87 | TACR2 (0.78) | ALDH1A1MAPTMEN1KMT2AFDPS | |
| SCHEMBL1353565 | 0.87 | ALDH1A1 (0.64) | ALDH1A1MAPTMEN1KMT2AFDPS | |
| SCHEMBL28666354 | 0.87 | ALDH1A1 (0.74) | ALDH1A1MAPTMEN1KMT2AFDPS | |
| SCHEMBL161066 | 0.87 | ALDH1A1 (0.73) | ALDH1A1MAPTMEN1KMT2AFDPS | |
| SCHEMBL29956112 | 0.86 | SMN1; SMN2 (0.76) | ALDH1A1MAPTMEN1KMT2AFDPS | |
| SCHEMBL25221916 | 0.86 | ALDH1A1 (0.60) | ALDH1A1MAPTMEN1KMT2AFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023541-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED | 2013-01-24 | — | — | US | disclosed |
| US-20130023541-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED | 2013-01-24 | — | — | US | disclosed |
| WO-2013006596-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2013-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023541-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | KCNB1, KCNB2, SCNN1B | ALDH1A1 2656/4885MAPT 1880/4885MEN1 4275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.