Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2225364 | 0.95 | MAPT (0.52) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2222936 | 0.88 | MEN1 (0.57) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2222446 | 0.88 | KDM4E (0.61) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2222272 | 0.87 | MAPT (0.53) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2221001 | 0.85 | MAPT (0.52) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2226472 | 0.85 | KDM4E (0.55) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2222807 | 0.85 | KDM4E (0.55) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2223906 | 0.84 | MAPT (0.51) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2227231 | 0.83 | KDM4E (0.49) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL12516900 | 0.83 | KDM4E (0.49) | MAPTKDM4EPOLBNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013006596-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2013-01-10 | — | — | WO | disclosed |