Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14487939 | 1.00 | LMNA (0.47) | LMNATSHRNPSR1GAAALDH1A1 | |
| SCHEMBL14487355 | 0.84 | POLB (0.40) | TSHRGAAALDH1A1HTTKDM4E | |
| SCHEMBL20371748 | 0.84 | POLB (0.40) | TSHRGAAALDH1A1HTTKDM4E | |
| SCHEMBL14487337 | 0.78 | LMNA (0.47) | LMNATSHRNPSR1GAAALDH1A1 | |
| SCHEMBL23502063 | 0.75 | — | — | |
| SCHEMBL14489168 | 0.75 | LMNA (0.38) | LMNATSHRNPSR1ALDH1A1POLQ | |
| SCHEMBL22002215 | 0.73 | LMNA (0.45) | LMNATSHRNPSR1GAAALDH1A1 | |
| SCHEMBL14484690 | 0.72 | LMNA (0.53) | LMNATSHRNPSR1GAAALDH1A1 | |
| SCHEMBL14487433 | 0.72 | LMNA (0.44) | LMNATSHRNPSR1GAAALDH1A1 | |
| SCHEMBL15995925 | 0.71 | LMNA (0.43) | LMNATSHRNPSR1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013006738-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. (US) | 2013-01-10 | — | — | WO | disclosed |