Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL384908 | 1.00 | L3MBTL1 (0.61) | L3MBTL1GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL27818229 | 0.80 | GAA (0.85) | L3MBTL1GAASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL664938 | 0.80 | GAA (0.85) | L3MBTL1GAASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL23606754 | 0.79 | SMN1; SMN2 (0.46) | L3MBTL1GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL13823415 | 0.79 | L3MBTL1 (0.43) | L3MBTL1GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL14224158 | 0.79 | L3MBTL1 (0.43) | L3MBTL1GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL24335434 | 0.78 | GAA (0.55) | L3MBTL1GAASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL24335302 | 0.78 | GAA (0.55) | L3MBTL1GAASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL3668041 | 0.77 | GAA (1.00) | L3MBTL1GAASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4826390 | 0.76 | SMN1; SMN2 (0.41) | L3MBTL1GAASMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2289893-B1 | Haloaryl substituted aminopurines for use in treatment | SIGNAL PHARM LLC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2289893-A1 | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith | Signal Pharmaceuticals LLC (US) | 2011-03-02 | — | — | EP | disclosed |