Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345091 | 0.89 | CDK5 (0.51) | KDM4ECDK5CDK5R1ALDH1A1DYRK1A | |
| SCHEMBL5345568 | 0.88 | CDK5 (0.51) | KDM4ECDK5CDK5R1ALDH1A1DYRK1A | |
| SCHEMBL5347535 | 0.88 | ALDH1A1 (0.51) | KDM4ECDK5CDK5R1ALDH1A1DYRK1A | |
| Hydrochloric Acid SCHEMBL5345553 | 0.87 | CDK5 (0.50) | KDM4ECDK5CDK5R1ALDH1A1DYRK1A | |
| Hydrochloric Acid SCHEMBL5345510 | 0.87 | ALDH1A1 (0.50) | KDM4ECDK5CDK5R1ALDH1A1DYRK1A | |
| SCHEMBL5347630 | 0.86 | CDK5 (0.54) | KDM4ECDK5CDK5R1ALDH1A1DYRK1A | |
| SCHEMBL5345281 | 0.86 | CDK5 (0.54) | KDM4ECDK5CDK5R1ALDH1A1DYRK1A | |
| SCHEMBL5341523 | 0.86 | CDK5 (0.54) | KDM4ECDK5CDK5R1ALDH1A1DYRK1A | |
| SCHEMBL5339135 | 0.85 | CDK5 (0.53) | CDK5CDK5R1ALDH1A1HTTDYRK1A | |
| SCHEMBL5342527 | 0.83 | CDK5 (0.60) | CDK5CDK5R1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |