Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 10/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | ESRRA | P11474 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ESRRB | O95718 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5353798 | 1.00 | LMNA (0.58) | LMNAHSD17B10ESR1ESR2HDAC3 | |
| SCHEMBL2357452 | 0.90 | LMNA (0.58) | LMNAHSD17B10ESR1ESR2HDAC3 | |
| SCHEMBL17302815 | 0.90 | LMNA (0.58) | LMNAHSD17B10ESR1ESR2HDAC3 | |
| SCHEMBL6841525 | 0.88 | ESR1 (0.65) | LMNAHSD17B10ESR1ESR2HDAC3 | |
| SCHEMBL6462441 | 0.88 | LMNA (0.62) | LMNAHSD17B10ESR1ESR2HDAC3 | |
| SCHEMBL6841526 | 0.88 | ESR1 (0.65) | LMNAHSD17B10ESR1ESR2HDAC3 | |
| SCHEMBL16485502 | 0.88 | ESR1 (0.65) | LMNAHSD17B10ESR1ESR2HDAC3 | |
| SCHEMBL14569704 | 0.88 | ESR1 (0.65) | LMNAHSD17B10ESR1ESR2HDAC3 | |
| SCHEMBL6840976 | 0.88 | LMNA (0.62) | LMNAHSD17B10ESR1ESR2HDAC3 | |
| SCHEMBL6465985 | 0.87 | LMNA (0.61) | LMNAHSD17B10ESR1ESR2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196081-B2 | Compounds with hydroxycarbonyl-halogenoalkyl side chains | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-03-27 | — | — | US | disclosed |
| US-7196081-B2 | Compounds with hydroxycarbonyl-halogenoalkyl side chains | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-03-27 | — | — | US | disclosed |