Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8364956 | 0.94 | CYP19A1 (0.76) | CYP19A1KMT2ATSHRALDH1A1GPBAR1 | |
| SCHEMBL20079364 | 0.91 | CYP19A1 (0.73) | CYP19A1KMT2ATSHRALDH1A1GPBAR1 | |
| SCHEMBL14560485 | 0.85 | CYP19A1 (0.56) | CYP19A1KMT2ATSHRALDH1A1MEN1 | |
| SCHEMBL23253026 | 0.84 | KMT2A (0.55) | CYP19A1KMT2ATSHRMEN1SMN1; SMN2 | |
| SCHEMBL16350192 | 0.84 | TSHR (0.62) | CYP19A1KMT2ATSHRGPBAR1MEN1 | |
| SCHEMBL14560487 | 0.81 | ADRA1D (0.56) | CYP19A1KMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL26744125 | 0.81 | KMT2A (0.58) | CYP19A1KMT2ATSHRALDH1A1MEN1 | |
| SCHEMBL1552809 | 0.81 | CYP19A1 (1.00) | CYP19A1KMT2AMEN1SMN1; SMN2MIF | |
| SCHEMBL14560486 | 0.80 | CYP19A1 (0.57) | CYP19A1KMT2ATSHRALDH1A1MEN1 | |
| SCHEMBL31030081 | 0.78 | KMT2A (0.58) | CYP19A1KMT2ATSHRMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7192967-B1 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents | ASTELLAS PHARMA GMBH (DE) | 2007-03-20 | — | — | US | disclosed |