Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RGS12 | O14924 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644739 | 0.86 | LCK (0.57) | LCKKMT2AMEN1HTTLMNA | |
| SCHEMBL6310937 | 0.84 | LCK (0.57) | LCKHTTRAB9ASMN1; SMN2NPC1 | |
| Benzene SCHEMBL28080829 | 0.81 | LCK (0.53) | LCKALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL14560461 | 0.81 | LCK (0.53) | LCKALDH1A1KMT2AMEN1RAB9A | |
| Hydrochloric Acid SCHEMBL5389994 | 0.80 | LCK (0.68) | LCKRAB9ASMN1; SMN2L3MBTL1NR1H2 | |
| SCHEMBL28080838 | 0.80 | GSK3A (0.61) | KDM4ELCKALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL14560466 | 0.80 | ALDH1A1 (0.53) | LCKALDH1A1NR1H2NR1H3 | |
| SCHEMBL8103991 | 0.80 | PTGS1 (0.56) | LCKKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL7972585 | 0.80 | PTGS1 (0.56) | LCKKMT2AMEN1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL5397618 | 0.79 | LCK (0.66) | LCKRAB9ASMN1; SMN2L3MBTL1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7192967-B1 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents | ASTELLAS PHARMA GMBH (DE) | 2007-03-20 | — | — | US | disclosed |