Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.69 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.69 |
| ▸ | PIM1 | P11309 | 3/20 | 0.57 |
| ▸ | PRKCB | P05771 | 3/20 | 0.57 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.57 |
| ▸ | CDK4 | P11802 | 2/20 | 0.57 |
| ▸ | PRKACA | P17612 | 2/20 | 0.57 |
| ▸ | PRKACG | P22612 | 2/20 | 0.57 |
| ▸ | PRKACB | P22694 | 2/20 | 0.57 |
| ▸ | CCND1 | P24385 | 2/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 2/20 | 0.57 |
| ▸ | PRKCA | P17252 | 2/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | PRKCG | P05129 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.57 |
| ▸ | PRKCH | P24723 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14560475 | 0.93 | SIRT2 (0.65) | SIRT2SIRT1PIM1PRKCBCCNE2 | |
| SCHEMBL14560480 | 0.85 | SIRT2 (0.67) | SIRT2SIRT1PIM1PRKCBCCNE2 | |
| SCHEMBL14560483 | 0.84 | SIRT2 (0.65) | SIRT2SIRT1PIM1PRKCBCCNE2 | |
| SCHEMBL14560484 | 0.83 | SIRT2 (0.63) | SIRT2SIRT1PIM1PRKCBCCNE2 | |
| SCHEMBL14560482 | 0.82 | SIRT2 (0.59) | SIRT2SIRT1PIM1PRKCBCCNE2 | |
| SCHEMBL3945882 | 0.82 | SIRT2 (1.00) | SIRT2SIRT1PIM1PRKCBCCNE2 | |
| SCHEMBL30958473 | 0.82 | SIRT2 (1.00) | SIRT2SIRT1PIM1PRKCBCCNE2 | |
| SCHEMBL7193605 | 0.82 | SIRT2 (1.00) | SIRT2SIRT1PIM1PRKCBCCNE2 | |
| SCHEMBL14560476 | 0.80 | SIRT2 (0.60) | SIRT2SIRT1PIM1PRKCBCCNE2 | |
| SCHEMBL8478365 | 0.80 | SIRT2 (0.63) | SIRT2SIRT1PIM1PRKCBCCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7192967-B1 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents | ASTELLAS PHARMA GMBH (DE) | 2007-03-20 | — | — | US | disclosed |
| US-7192967-B1 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents | ASTELLAS PHARMA GMBH (DE) | 2007-03-20 | — | — | US | disclosed |