Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 1.00 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 1.00 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.63 |
| ▸ | PRKCB | P05771 | 5/20 | 0.62 |
| ▸ | PIM1 | P11309 | 3/20 | 0.62 |
| ▸ | CDK4 | P11802 | 3/20 | 0.62 |
| ▸ | CCND1 | P24385 | 3/20 | 0.62 |
| ▸ | PRKACA | P17612 | 3/20 | 0.62 |
| ▸ | PRKACG | P22612 | 3/20 | 0.62 |
| ▸ | PRKACB | P22694 | 3/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.62 |
| ▸ | PRKCA | P17252 | 2/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | PRKCG | P05129 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30958473 | 1.00 | SIRT2 (1.00) | SIRT2SIRT1RPS6KB1PRKCBPIM1 | |
| SCHEMBL5343477 | 0.89 | SIRT2 (0.80) | SIRT2SIRT1RPS6KB1PRKCBPIM1 | |
| SCHEMBL5682604 | 0.89 | SIRT2 (0.80) | SIRT2SIRT1RPS6KB1PRKCBPIM1 | |
| SCHEMBL7504252 | 0.89 | SIRT2 (0.80) | SIRT2SIRT1RPS6KB1PRKCBPIM1 | |
| SCHEMBL8354590 | 0.87 | SIRT2 (0.76) | SIRT2SIRT1RPS6KB1PRKCBPIM1 | |
| SCHEMBL7195523 | 0.87 | CCNT1 (0.81) | SIRT2SIRT1RPS6KB1PRKCBPIM1 | |
| SCHEMBL5683235 | 0.87 | SIRT2 (0.76) | SIRT2SIRT1RPS6KB1PRKCBPIM1 | |
| SCHEMBL5682637 | 0.87 | SIRT2 (0.76) | SIRT2SIRT1RPS6KB1PRKCBPIM1 | |
| SCHEMBL8703825 | 0.86 | SIRT2 (0.74) | SIRT2SIRT1RPS6KB1PRKCBPIM1 | |
| SCHEMBL7825953 | 0.85 | SIRT2 (0.72) | SIRT2SIRT1RPS6KB1PRKCBPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478643-B | Indoles [2,3-a] pyrroles [3,4-c] carbazole -5,7- diketone -6- virtue hydrazone compounds and preparation method thereof and the application in anticancer drug | 河南师范大学 | 2018-07-10 | — | — | CN | claimed |
| CN-106432250-B | Indoles [2,3-a] pyrroles [3,4-c] carbazole -5,7- diketone -6- (thiosemicarbazone) compounds with active anticancer and its preparation method and application | 河南师范大学 | 2018-07-10 | — | — | CN | claimed |
| CN-104710412-B | 3,4-bi(3-benzpyrole)-2,5-dione-1-pyrrole thiourea compound with antitumor activity and preparation method and application thereof | 河南师范大学 | 2017-03-22 | — | — | CN | claimed |
| CN-106478643-A | Fragrant hydrazone compounds of indole [2,3 a] pyrroles [3,4 c] carbazole 5,7 diketone 6 and preparation method thereof and the application in cancer therapy drug | 河南师范大学 | 2017-03-08 | — | — | CN | claimed |
| CN-106432250-A | Indole [2,3-a] pyrrole[3,4-c] carbazole-5,7-diketone-6-thiosemicarbazone compounds with antitumor activity as well as preparation method and application of compounds | 河南师范大学 | 2017-02-22 | — | — | CN | claimed |
| CN-104496970-B | 3,4-bi(3-indole)-2,5-dione-3-pyrrolineimine compound and preparation method and application of compound | 河南师范大学 | 2017-01-11 | — | — | CN | claimed |
| CN-104710412-A | 3,4-bi(3-benzpyrole)-2,5-dione-1-pyrroleimine thiourea compound with antitumor activity and preparation method and application thereof | UNIV HENAN NORMAL | 2015-06-17 | — | — | CN | claimed |
| CN-104496970-A | 3,4-bi(3-indole)-2,5-dione-3-pyrrolineimine compound, preparation method of compound and application of compound in anti-cancer drug | UNIV HENAN NORMAL | 2015-04-08 | — | — | CN | claimed |
| US-20060099568-A1 | Signals and molecular species involved in senescence | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2006-05-11 | — | — | US | claimed |
| US-6284783-B1 | Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis | THE UAB RESEARCH FOUNDATION | 2001-09-04 | — | — | US | claimed |
| JP-7238044-A | — | — | None | — | — | JP | disclosed |
| CN-106432250-B | Indoles [2,3-a] pyrroles [3,4-c] carbazole -5,7- diketone -6- (thiosemicarbazone) compounds with active anticancer and its preparation method and application | 河南师范大学 | 2018-07-10 | — | — | CN | disclosed |
| CN-106478643-B | Indoles [2,3-a] pyrroles [3,4-c] carbazole -5,7- diketone -6- virtue hydrazone compounds and preparation method thereof and the application in anticancer drug | 河南师范大学 | 2018-07-10 | — | — | CN | disclosed |
| US-20170216360-A1 | METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS | THE GENERAL HOSPITAL CORPORATION | 2017-08-03 | — | — | US | disclosed |
| US-20170216360-A1 | METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS | THE GENERAL HOSPITAL CORPORATION | 2017-08-03 | — | — | US | disclosed |
| EP-0657411-A1 | Improved synthesis of bisindolylmaleimides | ELI LILLY AND COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |
| EP-0630242-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| EP-0630241-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993018766-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |
| WO-1993018765-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170216360-A1 | METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS | CXCL12, VCAM1, ICAM1 | SIRT2 2858/4885SIRT1 1581/4885RPS6KB1 1801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.