Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.45 |
| ▸ | HTR2A | P28223 | 6/20 | 0.45 |
| ▸ | HTR2B | P41595 | 5/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | DOCK5 | Q9H7D0 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14566263 | 0.83 | HTR2C (0.36) | HTR2CHTR2AHTR2BMALT1DOCK5 | |
| SCHEMBL12574815 | 0.73 | EGLN1 (0.46) | — | |
| SCHEMBL11819635 | 0.72 | ATM (0.46) | HTR2CHTR2AHTR2BCCR1TSHR | |
| SCHEMBL20813839 | 0.70 | HRH3 (0.46) | — | |
| SCHEMBL4814583 | 0.70 | USP30 (0.55) | MALT1DOCK5 | |
| SCHEMBL5827625 | 0.68 | MCHR1 (0.47) | HTR2CHTR2AHTR2BTSHRMCOLN3 | |
| SCHEMBL20813850 | 0.67 | LIPE (0.53) | — | |
| SCHEMBL20814118 | 0.67 | LIPE (0.53) | — | |
| SCHEMBL3228974 | 0.66 | MAPT (0.49) | CCR1TSHRMCOLN3LMNAMAPT | |
| SCHEMBL20814122 | 0.66 | LIPE (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027734-A2 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX, INC. (US) | 2007-03-08 | — | — | WO | disclosed |