Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL803513 | 0.81 | HTT (0.51) | MAPTRAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL14572029 | 0.77 | MAPT (0.43) | MAPTRAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL5621347 | 0.77 | MAPT (0.43) | MAPTRAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL5621344 | 0.77 | MAPT (0.43) | MAPTRAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL13548832 | 0.74 | MAPK14 (0.56) | MAPTRAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL31532073 | 0.73 | SRD5A1 (0.51) | MAPTRAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL883773 | 0.73 | SRD5A1 (0.51) | MAPTRAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL1270477 | 0.73 | L3MBTL1 (0.44) | MAPTRAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL1270478 | 0.73 | L3MBTL1 (0.44) | MAPTRAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL10247479 | 0.73 | L3MBTL1 (0.44) | MAPTRAB9ANPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027855-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-03-08 | — | — | WO | disclosed |