Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 15/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3535003 | 0.97 | MAPT (0.56) | PTGER4MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL14200323 | 0.84 | MAPT (0.52) | PTGER4MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL14539474 | 0.83 | MAPT (0.51) | PTGER4MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL3537345 | 0.82 | PTGER4 (0.79) | PTGER4MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL12991931 | 0.80 | PTGER4 (0.42) | PTGER4MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL14199639 | 0.79 | MAPT (0.67) | PTGER4MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL3538298 | 0.79 | HPGD (0.41) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL14568307 | 0.78 | HIF1A (0.41) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL3534674 | 0.78 | PTGER4 (0.79) | PTGER4MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL3534513 | 0.77 | MAPT (0.64) | PTGER4MAPTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196089-B2 | EP4 receptor antagonists | ASTERAND UK LIMITED (GB) | 2007-03-27 | — | — | US | disclosed |
| US-7196089-B2 | EP4 receptor antagonists | ASTERAND UK LIMITED (GB) | 2007-03-27 | — | — | US | disclosed |