Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.64 |
| ▸ | PLK3 | Q9H4B4 | 13/20 | 0.64 |
| ▸ | NEK2 | P51955 | 4/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | PIM1 | P11309 | 3/20 | 0.64 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.54 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.52 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.52 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406004 | 0.93 | PLK1 (0.74) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL5002940 | 0.87 | PLK1 (0.66) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL4398666 | 0.85 | PLK1 (0.67) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL4404130 | 0.84 | PLK1 (0.62) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL5006623 | 0.83 | PLK1 (0.61) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| Trifluoroacetic Acid SCHEMBL4395214 | 0.82 | PLK1 (0.63) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL4395531 | 0.81 | PLK1 (0.54) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL13592915 | 0.80 | PLK1 (0.61) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL5002731 | 0.79 | PLK1 (0.78) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| Gsk-579289A SCHEMBL31060734 | 0.78 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |