Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17550073 | 0.82 | TSHR (0.39) | TSHRTP53TDP1CA12CA1 | |
| SCHEMBL179681 | 0.82 | TSHR (0.39) | TSHRTP53TDP1CA12CA1 | |
| SCHEMBL18461807 | 0.82 | MEN1 (0.41) | TSHRTP53TDP1CA12CA1 | |
| SCHEMBL10308511 | 0.80 | — | — | |
| SCHEMBL23969048 | 0.80 | MEN1 (0.50) | TSHRTP53TDP1CA12CA1 | |
| SCHEMBL12391214 | 0.78 | TSHR (0.43) | TSHRTP53TDP1CA12CA1 | |
| SCHEMBL21558044 | 0.77 | TSHR (0.34) | TSHRTP53TDP1CA12CA1 | |
| SCHEMBL11070076 | 0.76 | TSHR (0.42) | TSHRTP53TDP1CA12CA1 | |
| SCHEMBL14751757 | 0.76 | CA12 (0.42) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL10902617 | 0.74 | TP53 (0.48) | TSHRTP53TDP1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186826-B2 | Phosphorus-containing compounds and uses thereof | ARIAD GENE THERAPEUTICS, INC. (US) | 2007-03-06 | — | — | US | disclosed |