Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | NCK1 | P16333 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31434423 | 0.81 | NCK1 (0.50) | KDM4ERAB9AMAPTCYP1A2NCK1 | |
| SCHEMBL19941893 | 0.81 | NCK1 (0.50) | KDM4ERAB9AMAPTCYP1A2NCK1 | |
| SCHEMBL14597730 | 0.80 | BACE1 (0.47) | KDM4ELMNABACE1MEN1KMT2A | |
| SCHEMBL3533290 | 0.80 | CYP1A2 (0.62) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL27459309 | 0.79 | ALDH1A1 (0.44) | LMNACYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL3652540 | 0.75 | CYP1A2 (0.57) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL30896202 | 0.74 | KDM4E (0.55) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6834551 | 0.74 | KDM4E (0.55) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8935104 | 0.74 | ALDH1A1 (0.53) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| Bromide SCHEMBL28322147 | 0.73 | ALDH1A1 (0.54) | KDM4ENPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196080-B2 | Respiratory system disordeers; chronic obstructive pulminary disease | ASTELLAS PHARMA INC. (JP) | 2007-03-27 | — | — | US | disclosed |
| US-7196080-B2 | Respiratory system disordeers; chronic obstructive pulminary disease | ASTELLAS PHARMA INC. (JP) | 2007-03-27 | — | — | US | disclosed |