⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34466311 | 0.95 | TSHR (1.00) | — | |
| SCHEMBL3052767 | 0.95 | TSHR (1.00) | — | |
| Pyridine SCHEMBL933604 | 0.95 | TSHR (1.00) | — | |
| Pyridine SCHEMBL180431 | 0.95 | TSHR (1.00) | — | |
| Benzene SCHEMBL1261317 | 0.95 | TSHR (1.00) | — | |
| Pyridine SCHEMBL9037865 | 0.95 | TSHR (1.00) | — | |
| Benzene SCHEMBL10751789 | 0.95 | TSHR (1.00) | — | |
| Pyridine SCHEMBL16 | 0.95 | — | — | |
| Pyridine SCHEMBL1654468 | 0.95 | — | — | |
| SCHEMBL30054932 | 0.95 | TSHR (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109651358-A | 4-aminopyridine derivative, its pharmaceutical composition, preparation method and application | 上海迪诺医药科技有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-108822155-A | It is a kind of miscellaneous with iridium complex and its organic luminescent device | 长春海谱润斯科技有限公司 | 2018-11-16 | — | — | CN | disclosed |
| CN-107108616-A | Radioactive halogen labeled pyrido [1,2-a ] benzimidazole derivative compound | 国立大学法人京都大学 | 2017-08-29 | — | — | CN | disclosed |
| CN-104302626-B | 4, 4-disubstituted-1, 4-dihydropyrimidines and their use as medicaments for the treatment of hepatitis b | 爱尔兰詹森科学公司 | 2016-09-07 | — | — | CN | disclosed |
| CN-103608346-B | As the 7-naphthyridine derivatives of hypoxia inducible factor (HIF) hydroxylase inhibitors | 菲布罗根有限公司 | 2016-06-15 | — | — | CN | disclosed |
| US-20150274661-A1 | INDOL-AMIDE COMPOUNDS AS BETA-AMYLOID INHBITORS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-01 | — | — | US | disclosed |
| EP-2909190-A1 | INDOL-AMIDE COMPOUNDS AS BETA-AMYLOID INHBITORS | F. Hoffmann-La Roche AG (CH) | 2015-08-26 | — | — | EP | disclosed |
| CN-104640853-A | Indole-amide compounds as beta-amyloid inhibitors | HOFFMANN LA ROCHE | 2015-05-20 | — | — | CN | disclosed |
| US-9034873-B2 | Pyridazine and pyrrole compounds, processes for obtaining them and uses | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2015-05-19 | — | — | US | disclosed |
| CN-104395305-A | Heterocyclic compounds and their uses | AMGEN INC | 2015-03-04 | — | — | CN | disclosed |
| EP-1165561-A1 | 6-SUBSTITUTED BIARYL PURINE DERIVATIVES AS POTENT CYCLIN/CDK INHIBITORS AND ANTIPROLIFERATIVE AGENTS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6265350-B1 | CONTROLLING HARMFUL FUNGI, INSECTS, ACARINA, MOLLUSKS AND NEMATODES | HOECHST SCHERING AGREVO GMBH (DE) | 2001-07-24 | — | — | US | disclosed |
| JP-2001064280-A | BIPYRIDINE EXPANDED WITH HETEROCYCLIC 5-MEMBERED RING AND ITS PRODUCTION | SONY CORP | 2001-03-13 | — | — | JP | disclosed |
| WO-2000055161-A1 | 6-SUBSTITUTED BIARYL PURINE DERIVATIVES AS POTENT CYCLIN/CDK INHIBITORS AND ANTIPROLIFERATIVE AGENTS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2000-09-21 | — | — | WO | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |
| CN-1214685-A | Farnesyl protein transfer inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1999-04-21 | — | — | CN | disclosed |
| EP-0892797-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030992-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |
| US-4556702-A | CATALYTIC SOLUTION POLYMERIZATION, THEN NEUTRALIZATION | AMERICAN CYANAMID COMPANY (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0130313-A2 | Oligomers and homopolymers of meta- or para-isopropenyl-alpha,alpha-dimethylbenzylisocyanate | AMERICAN CYANAMID COMPANY (US) | 1985-01-09 | — | — | EP | disclosed |