Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 13/20 | 0.62 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618027 | 0.83 | TTK (0.57) | TTK | |
| SCHEMBL5618750 | 0.82 | TTK (0.62) | TTKFLT3 | |
| SCHEMBL5618424 | 0.81 | TTK (0.57) | TTK | |
| SCHEMBL5618660 | 0.80 | TTK (0.46) | TTKFPR2MAPK1 | |
| SCHEMBL14573283 | 0.80 | TTK (0.46) | TTKFPR2MAPK1 | |
| SCHEMBL5617963 | 0.80 | TTK (0.55) | TTKFLT3MAPK1 | |
| SCHEMBL5617920 | 0.80 | TTK (0.55) | TTK | |
| SCHEMBL5618516 | 0.79 | TTK (0.59) | TTK | |
| SCHEMBL5618729 | 0.79 | TTK (0.56) | TTKFLT3 | |
| SCHEMBL5618589 | 0.79 | TTK (0.58) | TTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |