Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 8/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618660 | 1.00 | TTK (0.46) | TTKFGFR3KDRMAPTFGFR4 | |
| SCHEMBL14573285 | 0.80 | TTK (0.62) | TTKMAPK1FPR2 | |
| SCHEMBL14573284 | 0.73 | MAPT (0.39) | TTKFGFR3KDRMAPTLMNA | |
| SCHEMBL12271909 | 0.69 | FGFR3 (0.33) | FGFR3KDR | |
| SCHEMBL12272621 | 0.65 | DYRK1A (0.39) | FGFR3KDR | |
| SCHEMBL20597821 | 0.64 | CASR (0.66) | MAPK1TP53 | |
| SCHEMBL21611850 | 0.64 | CASR (0.66) | MAPK1TP53 | |
| SCHEMBL3668675 | 0.64 | CASR (0.66) | MAPK1TP53 | |
| SCHEMBL5617963 | 0.64 | TTK (0.55) | TTKMAPK1IDO1 | |
| SCHEMBL5618424 | 0.63 | TTK (0.57) | TTKKDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |