Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 14/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618995 | 0.82 | TTK (0.48) | TTKFLT3 | |
| SCHEMBL14573294 | 0.81 | TTK (0.50) | TTKAURKAFLT3 | |
| SCHEMBL6366899 | 0.81 | TTK (0.45) | TTKAURKAFLT3AURKB | |
| SCHEMBL5404932 | 0.80 | TTK (0.56) | TTK | |
| SCHEMBL5618421 | 0.79 | TTK (0.50) | TTKAURKAFLT3AURKB | |
| SCHEMBL5394669 | 0.79 | TTK (0.54) | TTK | |
| SCHEMBL5618443 | 0.78 | TTK (0.55) | TTK | |
| SCHEMBL5410621 | 0.77 | TTK (0.57) | TTK | |
| SCHEMBL14573296 | 0.76 | TTK (0.43) | TTKAURKAFLT3 | |
| SCHEMBL14573297 | 0.76 | TTK (0.43) | TTKAURKAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |