Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 14/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14573295 | 0.90 | TTK (0.41) | TTKFLT3AURKAADORA3MAPT | |
| SCHEMBL14573297 | 0.87 | TTK (0.43) | TTKFLT3AURKAADORA3 | |
| SCHEMBL5618446 | 0.80 | TTK (0.57) | TTKNPC1RAB9A | |
| SCHEMBL14573294 | 0.80 | TTK (0.50) | TTKFLT3AURKA | |
| SCHEMBL6366899 | 0.78 | TTK (0.45) | TTKFLT3AURKA | |
| SCHEMBL5618421 | 0.77 | TTK (0.50) | TTKFLT3AURKAMEN1KMT2A | |
| SCHEMBL14573293 | 0.76 | TTK (0.44) | TTKFLT3AURKA | |
| SCHEMBL5619174 | 0.76 | TTK (0.53) | TTKFLT3KDM4EALDH1A1 | |
| SCHEMBL5618589 | 0.72 | TTK (0.58) | TTKFLT3NPC1 | |
| SCHEMBL5618691 | 0.72 | TTK (0.53) | TTKFLT3KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |