Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 15/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5619411 | 0.91 | TTK (0.46) | TTKBRAFFLT3PTK6 | |
| SCHEMBL5618400 | 0.80 | TTK (0.48) | TTKFLT3 | |
| SCHEMBL5618158 | 0.76 | TTK (0.49) | TTKBRAFFLT3 | |
| SCHEMBL5619480 | 0.72 | TTK (0.49) | TTKBRAFFLT3PTK6 | |
| SCHEMBL5618333 | 0.71 | TTK (0.55) | TTKBRAFFLT3PTK6 | |
| SCHEMBL5618727 | 0.71 | TTK (0.50) | TTKBRAFFLT3 | |
| SCHEMBL5617963 | 0.70 | TTK (0.55) | TTKBRAFFLT3 | |
| SCHEMBL5406217 | 0.69 | FLT3 (0.53) | TTKFLT3 | |
| SCHEMBL5618058 | 0.69 | TTK (0.53) | TTKBRAF | |
| SCHEMBL5618446 | 0.69 | TTK (0.57) | TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |