Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 14/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14573298 | 0.91 | TTK (0.42) | TTKBRAFFLT3PTK6 | |
| SCHEMBL5618400 | 0.89 | TTK (0.48) | TTKFLT3IDO1 | |
| SCHEMBL5618158 | 0.85 | TTK (0.49) | TTKBRAFFLT3IDO1 | |
| SCHEMBL5618727 | 0.80 | TTK (0.50) | TTKBRAFFLT3IDO1 | |
| SCHEMBL5618353 | 0.77 | TTK (0.60) | TTKFLT3 | |
| SCHEMBL5618971 | 0.76 | TTK (0.50) | TTKFLT3IDO1 | |
| SCHEMBL5618704 | 0.76 | TTK (0.48) | TTKFLT3 | |
| SCHEMBL5619480 | 0.76 | TTK (0.49) | TTKBRAFFLT3PTK6 | |
| SCHEMBL5618960 | 0.75 | TTK (0.55) | TTK | |
| SCHEMBL5618333 | 0.75 | TTK (0.55) | TTKBRAFFLT3PTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | claimed |
| US-20050009832-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN, INC. | 2005-01-13 | — | — | US | claimed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-20050009832-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN, INC. | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009832-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | MAP3K8, MAP3K2, MAP3K5 | TTK 69/4885BRAF 61/4885FLT3 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.