Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL1458160 | 1.00 | CYP2C19 (0.44) | CYP2C19EPHX1PKMSMN1; SMN2LMNA | |
| SCHEMBL1458049 | 0.85 | CYP2C19 (0.51) | CYP2C19EPHX1PKMSMN1; SMN2LMNA | |
| SCHEMBL6125635 | 0.85 | CYP2C19 (0.51) | CYP2C19EPHX1PKMSMN1; SMN2LMNA | |
| SCHEMBL1458053 | 0.85 | CYP2C19 (0.51) | CYP2C19EPHX1PKMSMN1; SMN2LMNA | |
| SCHEMBL10584727 | 0.82 | EPHX1 (0.54) | CYP2C19EPHX1PKMSMN1; SMN2LMNA | |
| SCHEMBL7556318 | 0.75 | CYP2C19 (0.38) | CYP2C19EPHX1PKMSMN1; SMN2SLC6A3 | |
| SCHEMBL28678702 | 0.72 | CYP2C19 (0.45) | CYP2C19PKMSMN1; SMN2LMNASLC6A3 | |
| Silver SCHEMBL10959532 | 0.71 | CYP2C19 (0.71) | CYP2C19EPHX1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1758751 | 0.70 | CYP2C19 (0.40) | CYP2C19SMN1; SMN2SLC6A3ALDH1A1CYP2D6 | |
| SCHEMBL10953879 | 0.68 | EPHX1 (0.49) | CYP2C19EPHX1SMN1; SMN2LMNASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123218-A1 | COMBINATION THERAPY | FOLLICA, INC. (US) | 2011-10-06 | — | — | WO | disclosed |
| US-20110130711-A1 | HAIR GROWTH TREATMENT | FOLLICA, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20110130748-A1 | BODY SURFACE TREATMENT | FOLLICA, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20110130706-A1 | SEQUENTIAL BODY SURFACE TREATMENT | FOLLICA, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| WO-2011031977-A1 | INTERMITTENT AND PULSE LITHIUM TREATMENTS FOR SCAR REVISION AND WOUND HEALING | FOLLICA, INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| WO-2011031990-A1 | INTERMITTENT AND PULSE LITHIUM TREATMENTS FOR MODULATING HAIR GROWTH | FOLLICA, INC. (US) | 2011-03-17 | — | — | WO | disclosed |