Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.42 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965223 | 0.83 | KDM4E (0.47) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL27974265 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL31325947 | 0.83 | TPMT (0.50) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL5187719 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL29091654 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL16952228 | 0.80 | ALDH1A1 (0.40) | SMN1; SMN2KMT2APOLBMAPTHPGD | |
| SCHEMBL596707 | 0.78 | KDM4E (0.52) | SMN1; SMN2KMT2APOLBMAPTKDM4E | |
| SCHEMBL295414 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL4261329 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL1047515 | 0.76 | ALDH1A1 (0.56) | HPGDCYP2C9ALDH1A1CYP3A4CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011027106-A1 | THERAPEUTIC ARYL-AM I DO-ARYL COMPOUNDS AND THEIR USE | KING'S COLLEGE LONDON (GB) | 2011-03-10 | — | — | WO | disclosed |