Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | NAT1 | P18440 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.53 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040479 | 0.87 | NPC1 (0.65) | NPC1MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL13848495 | 0.86 | PDE4B (0.58) | NPC1MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL10708397 | 0.85 | MEN1 (0.74) | NPC1MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL10708392 | 0.85 | MEN1 (0.74) | NPC1MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL13044217 | 0.84 | MEN1 (0.77) | NPC1MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL14181813 | 0.83 | MAPT (0.58) | NPC1MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL14713049 | 0.83 | METAP1 (0.58) | NPC1MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL16442345 | 0.81 | NPC1 (1.00) | NPC1MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL29367529 | 0.81 | NPC1 (1.00) | NPC1MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL5469692 | 0.81 | NPC1 (1.00) | NPC1MAPTALDH1A1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070026398-A1 | Protein tyrosine phosphatase-prl-1 a a marker and therapeutic target for pancreatic cancer | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2007-02-01 | — | — | US | disclosed |
| US-20070026398-A1 | Protein tyrosine phosphatase-prl-1 a a marker and therapeutic target for pancreatic cancer | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2007-02-01 | — | — | US | disclosed |