Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638586 | 0.83 | TACR1 (0.42) | TACR1GPBAR1EPAS1 | |
| SCHEMBL4637956 | 0.80 | ALDH1A1 (0.46) | TACR1GPBAR1EPAS1ALDH1A1PIM1 | |
| SCHEMBL14144832 | 0.76 | TACR1 (0.37) | TACR1GPBAR1EPAS1ALDH1A1LMNA | |
| SCHEMBL4707969 | 0.72 | CDC7 (0.42) | TACR1ALDH1A1ROCK2PIM1GSK3B | |
| SCHEMBL4638855 | 0.71 | EPAS1 (0.50) | TACR1HSP90AA1HSP90AB1GPBAR1EPAS1 | |
| SCHEMBL5795073 | 0.71 | HSP90AA1 (0.53) | TGM2HSP90AA1HSP90AB1ALDH1A1LMNA | |
| SCHEMBL4639409 | 0.68 | TACR1 (0.39) | TACR1GPBAR1EPAS1ALDH1A1 | |
| SCHEMBL2378228 | 0.68 | P2RX1 (0.53) | TGM2EPAS1ALDH1A1LMNA | |
| SCHEMBL5797524 | 0.68 | ALDH1A1 (0.50) | TACR1GPBAR1ALDH1A1 | |
| SCHEMBL5797317 | 0.67 | HSP90AA1 (0.58) | TGM2HSP90AA1HSP90AB1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179804-B2 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179804-B2 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-02-20 | — | — | US | disclosed |