SCHEMBL14587243

SCHEMBL14587243

COC(=O)CC(CC(C)(C)c1cc(F)ccc1OC)(O[Si](C)(C)C)C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 12/20 0.50
NR3C1 P04150 19/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14619477 1.00 NR3C2 (0.50) NR3C2NR3C1
SCHEMBL14064858 0.88 NR3C1 (0.39) NR3C2NR3C1
SCHEMBL10089057 0.88 NR3C1 (0.44) NR3C2NR3C1
SCHEMBL14587242 0.82 NR3C1 (0.64) NR3C2NR3C1
SCHEMBL4490249 0.80 NR3C2 (0.51) NR3C2NR3C1
SCHEMBL4772156 0.74 NR3C1 (0.69) NR3C2NR3C1
SCHEMBL4772164 0.74 NR3C1 (0.69) NR3C2NR3C1
SCHEMBL3652051 0.73 NR3C2 (0.65) NR3C2NR3C1
SCHEMBL3954499 0.72 NR3C2 (0.68) NR3C2NR3C1
SCHEMBL4817160 0.72 NR3C2 (0.61) NR3C2NR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7179919-B2 Stereoselective synthesis of certain trifluoromethyl-substituted alcohols BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2007-02-20 US disclosed