Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 14/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4203042 | 0.96 | KEAP1 (0.61) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL4213705 | 0.96 | KEAP1 (0.61) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL4203592 | 0.96 | KEAP1 (0.61) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL2788610 | 0.95 | KEAP1 (0.59) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL4243228 | 0.92 | KEAP1 (0.50) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL27749385 | 0.92 | KEAP1 (0.50) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL4243455 | 0.92 | KEAP1 (0.50) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL9856165 | 0.87 | KEAP1 (0.47) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL13928640 | 0.85 | CHRM3 (0.57) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL4245314 | 0.84 | CHRM3 (0.60) | KEAP1NFE2L2CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490003-A | New alkyl esters of cyclic amino alcohols with muscarinic m3 receptor antagonist activity, useful for treating e.g. chronic bronchial obstruction, asthma and overactive bladder | ASTRAZENECA AB (SE) | 2009-07-22 | — | — | CN | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |