Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 16/20 | 0.85 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.85 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.85 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.85 |
| ▸ | CDK2 | P24941 | 10/20 | 0.84 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.84 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.77 |
| ▸ | RAB9A | P51151 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | CLK1 | P49759 | 1/20 | 0.77 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.77 |
| ▸ | CDK7 | P50613 | 6/20 | 0.65 |
| ▸ | CDK4 | P11802 | 4/20 | 0.65 |
| ▸ | CCND1 | P24385 | 4/20 | 0.65 |
| ▸ | CCNH | P51946 | 4/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | CDK9 | P50750 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827674 | 0.91 | CDK2 (1.00) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL4422862 | 0.89 | CDK1 (0.81) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL4422868 | 0.89 | CDK1 (0.81) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL6016617 | 0.87 | CDK1 (0.81) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL6016614 | 0.87 | CDK1 (0.81) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL15118140 | 0.86 | CDK2 (0.79) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL13001904 | 0.85 | CDK2 (0.80) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL1354766 | 0.85 | CDK1 (0.69) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL1443682 | 0.85 | CDK1 (1.00) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL3721146 | 0.85 | CDK1 (1.00) | CDK1CCNB1CCNB2CCNB3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176312-B2 | Kinase inhibitor scaffolds and methods for their preparation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-02-13 | — | — | US | disclosed |