Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 6/20 | 0.81 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.81 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.81 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.81 |
| ▸ | CDK2 | P24941 | 8/20 | 0.79 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.78 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.75 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.73 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | CLK1 | P49759 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422868 | 1.00 | CDK1 (0.81) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL14587743 | 0.89 | CDK1 (0.85) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL5827674 | 0.89 | CDK2 (1.00) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| Myoseverin SCHEMBL13325947 | 0.88 | TDP1 (1.00) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| Myoseverin SCHEMBL29376276 | 0.88 | TDP1 (1.00) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL1443401 | 0.88 | CDK1 (0.85) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL3718983 | 0.88 | CDK1 (0.85) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL13359693 | 0.85 | TDP1 (0.90) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL6016614 | 0.85 | CDK1 (0.81) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL6016617 | 0.85 | CDK1 (0.81) | CDK1CCNB2CCNB1CCNB3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325931-A1 | USE OF CDK INHIBITORS FOR THE TREATMENT OF GRANULOCYTE MEDIATED DISORDERS | UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2009-12-31 | — | — | US | disclosed |
| US-7176312-B2 | Kinase inhibitor scaffolds and methods for their preparation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176312-B2 | Kinase inhibitor scaffolds and methods for their preparation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-02-13 | — | — | US | disclosed |