Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 6/20 | 0.46 |
| ▸ | FNTB | P49356 | 6/20 | 0.46 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14588485 | 0.84 | FNTA (0.51) | FNTAFNTBPGGT1BTP53MEN1 | |
| SCHEMBL14588484 | 0.81 | FNTA (0.49) | FNTAFNTBPGGT1BTP53CNR2 | |
| SCHEMBL6794461 | 0.78 | FNTA (0.46) | FNTAFNTBPGGT1BTP53CHEK1 | |
| SCHEMBL6794894 | 0.76 | FNTA (0.44) | FNTAFNTBPGGT1BTP53CNR2 | |
| SCHEMBL14588477 | 0.75 | FNTA (0.54) | FNTAFNTBMEN1KMT2A | |
| SCHEMBL6795186 | 0.75 | FNTA (0.54) | FNTAFNTBPGGT1BTP53SMN1; SMN2 | |
| SCHEMBL14588483 | 0.74 | FNTA (0.52) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL5656453 | 0.72 | FNTA (0.59) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL14588487 | 0.71 | FNTA (0.51) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL5543925 | 0.70 | FNTA (0.60) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173040-B2 | Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-06 | — | — | US | disclosed |
| US-7173040-B2 | Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-06 | — | — | US | disclosed |