Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ECE1 | P42892 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.49 |
| ▸ | FNTB | P49356 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149555 | 0.89 | ACE (0.57) | CASP1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29986695 | 0.89 | ACE (0.57) | CASP1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL468341 | 0.89 | ACE (0.57) | CASP1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29391753 | 0.89 | ACE (0.57) | CASP1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6138173 | 0.83 | P2RY14 (0.56) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6287655 | 0.82 | HDAC1 (0.50) | CASP1MAPTSMN1; SMN2ALDH1A1MMP2 | |
| SCHEMBL13278205 | 0.80 | ALOX15 (0.70) | MEN1KMT2AACEP2RY14HTT | |
| SCHEMBL3728145 | 0.80 | ALOX15 (0.70) | MEN1KMT2AACEP2RY14HTT | |
| SCHEMBL29987387 | 0.80 | ALOX15 (0.70) | MEN1KMT2AACEP2RY14HTT | |
| SCHEMBL8525238 | 0.80 | MEN1 (0.57) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173039-B2 | Protein kinase inhibitors | THERAVANCE, INC. (US) | 2007-02-06 | — | — | US | disclosed |