SCHEMBL1459280

SCHEMBL1459280

Cc1ccc(-c2ccc(O[C@H]3CN4CCC3CC4)nn2)c(F)c1

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.53
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
ALDH1A1 P00352 1/20 0.37
CHRM2 P08172 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
TLR7 Q9NYK1 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1459282 1.00 CHRNA7 (0.53) CHRNA7CYP1A2CYP2D6ALDH1A1CHRM2
SCHEMBL3842064 0.94 CHRNA7 (0.47) CHRNA7CYP1A2CYP2D6CHRM2CHRM1
SCHEMBL3839401 0.94 CHRNA7 (0.47) CHRNA7CYP1A2CYP2D6CHRM2CHRM1
SCHEMBL3839223 0.91 CHRNA7 (0.53) CHRNA7CYP1A2CYP2D6ALDH1A1CHRM2
SCHEMBL3839228 0.91 CHRNA7 (0.53) CHRNA7CYP1A2CYP2D6ALDH1A1CHRM2
SCHEMBL1460490 0.88 CHRNA7 (0.53) CHRNA7CHRM2CHRM1TLR7
SCHEMBL1460488 0.88 CHRNA7 (0.53) CHRNA7CHRM2CHRM1TLR7
SCHEMBL1146018 0.87 CHRNA7 (0.40) CHRNA7CHRM2CHRM1
SCHEMBL1146287 0.87 CHRNA7 (0.40) CHRNA7CHRM2CHRM1
SCHEMBL1146153 0.87 CHRNA7 (0.40) CHRNA7CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2480228-B1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2016-11-16 EP claimed
US-8236803-B2 Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists NOVARTIS AG (CH) 2012-08-07 US claimed
EP-1537104-B1 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS NOVARTIS AG (CH) 2009-11-11 EP claimed
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2025-02-04 US disclosed
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2022-10-06 US disclosed
US-20220211679-A1 ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS AG (CH) 2022-07-07 US disclosed
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2022-06-14 US disclosed
US-11311525-B2 Use of alpha 7 nicotinic acetylcholine receptor agonists NOVARTIS AG (CH) 2022-04-26 US disclosed
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2021-11-04 US disclosed
EP-2945633-B1 USE OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS AG (CH) 2021-06-30 EP disclosed
US-20200108035-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2020-04-09 US disclosed
US-20090054446-A1 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS NOVARTIS AG 2009-02-26 US disclosed
US-20080306081-A1 Combinations of Nicotinic Acetylcholine Alpha 7 Receptor Antagonists NOVARTIS AG (CH) 2008-12-11 US disclosed
US-20080306081-A1 Combinations of Nicotinic Acetylcholine Alpha 7 Receptor Antagonists NOVARTIS AG (CH) 2008-12-11 US disclosed
US-20080306081-A1 Combinations of Nicotinic Acetylcholine Alpha 7 Receptor Antagonists NOVARTIS AG (CH) 2008-12-11 US disclosed
US-20070249617-A1 Aza-bicycloalkyl ethers and their use as alpha7-nachr agonists NOVARTIS AG (CH) 2007-10-25 US disclosed
EP-1809285-A1 COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS Novartis AG (CH) 2007-07-25 EP disclosed
WO-2006048294-A1 COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS NOVARTIS AG (CH) 2006-05-11 WO disclosed
EP-1537104-A1 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONIST Novartis AG (CH) 2005-06-08 EP disclosed
WO-2004022556-A1 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONIST NOVARTIS AG (CH) 2004-03-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11311525-B2 Use of alpha 7 nicotinic acetylcholine receptor agonists CHRNA7, CHRNA1, CHRNA5 CHRNA7 1/4885CYP1A2 934/4885CYP2D6 1391/4885
US-20070249617-A1 Aza-bicycloalkyl ethers and their use as alpha7-nachr agonists CHRNA7, CHRNA1, CHRNE CHRNA7 1/4885CYP1A2 274/4885CYP2D6 613/4885
US-20090054446-A1 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS CHRNA7, CHRNA1, CHRNE CHRNA7 1/4885CYP1A2 274/4885CYP2D6 613/4885
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885CYP1A2 3801/4885CYP2D6 4172/4885
US-20220211679-A1 ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS CHRNA7, CHRNA1, CHRNA4 CHRNA7 1/4885CYP1A2 2465/4885CYP2D6 3919/4885
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885CYP1A2 3801/4885CYP2D6 4172/4885
US-20200108035-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885CYP1A2 3895/4885CYP2D6 4259/4885
US-20080306081-A1 Combinations of Nicotinic Acetylcholine Alpha 7 Receptor Antagonists CHRNA7, CHRNA4, CHRNA10 CHRNA7 1/4885CYP1A2 2253/4885CYP2D6 1816/4885
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885CYP1A2 3722/4885CYP2D6 4137/4885
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885CYP1A2 3895/4885CYP2D6 4259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.