Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842064 | 1.00 | CHRNA7 (0.47) | CHRNA7CHRM1CHRM2TLR7CYP1A2 | |
| SCHEMBL1459282 | 0.94 | CHRNA7 (0.53) | CHRNA7CHRM1CHRM2TLR7CYP1A2 | |
| SCHEMBL1459280 | 0.94 | CHRNA7 (0.53) | CHRNA7CHRM1CHRM2TLR7CYP1A2 | |
| SCHEMBL1146153 | 0.89 | CHRNA7 (0.40) | CHRNA7CHRM1CHRM2 | |
| SCHEMBL1146018 | 0.89 | CHRNA7 (0.40) | CHRNA7CHRM1CHRM2 | |
| SCHEMBL1146287 | 0.89 | CHRNA7 (0.40) | CHRNA7CHRM1CHRM2 | |
| SCHEMBL3839223 | 0.86 | CHRNA7 (0.53) | CHRNA7CHRM1CHRM2TLR7CYP1A2 | |
| SCHEMBL3839228 | 0.86 | CHRNA7 (0.53) | CHRNA7CHRM1CHRM2TLR7CYP1A2 | |
| SCHEMBL1460490 | 0.82 | CHRNA7 (0.53) | CHRNA7CHRM1CHRM2TLR7 | |
| SCHEMBL1460488 | 0.82 | CHRNA7 (0.53) | CHRNA7CHRM1CHRM2TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236803-B2 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |