Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 6/20 | 0.76 |
| ▸ | CHRNA7 | P36544 | 15/20 | 0.71 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.64 |
| ▸ | HTR3B | O95264 | 1/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1101795 | 1.00 | HTR3A (0.76) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| Hydrochloric Acid SCHEMBL1091297 | 0.99 | HTR3A (0.75) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL1101986 | 0.91 | HTR3A (0.78) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| Hydrochloric Acid SCHEMBL1090845 | 0.90 | HTR3A (0.77) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL20131925 | 0.87 | HTR3A (0.83) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL15796777 | 0.86 | HTR3A (0.75) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL1101798 | 0.86 | HTR3A (0.73) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL1101794 | 0.86 | HTR3A (1.00) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL1101796 | 0.86 | HTR3A (0.75) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL1101784 | 0.86 | HTR3A (1.00) | HTR3ACHRNA7HTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480228-A1 | USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS | Novartis AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011036167-A1 | USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS | NOVARTIS AG (CH) | 2011-03-31 | — | — | WO | disclosed |