Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.60 |
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.56 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.50 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14595088 | 0.89 | MET (0.75) | METKDRPDGFRBFGFR1TLK2 | |
| SCHEMBL14595082 | 0.87 | MET (0.69) | METKDRPDGFRBFGFR1TLK2 | |
| SCHEMBL5412076 | 0.86 | MET (0.79) | METKDRPDGFRBFGFR1TLK2 | |
| SCHEMBL14595081 | 0.84 | MET (0.63) | METKDRPDGFRBFGFR1TLK2 | |
| SCHEMBL5412102 | 0.83 | MET (0.54) | METKDRPDGFRBFGFR1 | |
| SCHEMBL2114525 | 0.83 | PDGFRB (0.69) | METKDRPDGFRBFGFR1TLK2 | |
| SCHEMBL14595085 | 0.82 | MET (0.73) | METKDRPDGFRBFGFR1TLK2 | |
| SCHEMBL31672543 | 0.81 | PDGFRB (0.83) | METKDRPDGFRBFGFR1TLK2 | |
| SCHEMBL31672462 | 0.81 | KDR (0.69) | KDRPDGFRBFGFR1TLK2PRKAA2 | |
| SCHEMBL31672526 | 0.81 | PDGFRB (0.69) | KDRPDGFRBFGFR1TLK2PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |