Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.69 |
| ▸ | KDR | P35968 | 11/20 | 0.64 |
| ▸ | PRKAA1 | Q13131 | 10/20 | 0.64 |
| ▸ | PRKAA2 | P54646 | 9/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.63 |
| ▸ | EGFR | P00533 | 3/20 | 0.63 |
| ▸ | GRK5 | P34947 | 3/20 | 0.63 |
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | PLK4 | O00444 | 2/20 | 0.63 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.63 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.63 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.63 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.63 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.63 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14595083 | 0.91 | KDR (0.72) | METKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL5414487 | 0.90 | AURKB (0.63) | METKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL14595085 | 0.89 | MET (0.73) | METKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL14595088 | 0.88 | MET (0.75) | METKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL3803695 | 0.87 | AURKA (0.64) | METKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL3803693 | 0.87 | AURKA (0.64) | METKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL5405465 | 0.85 | MET (0.82) | METKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL14595082 | 0.84 | MET (0.69) | METKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL15202708 | 0.84 | KDR (0.79) | METKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL15202709 | 0.83 | KDR (0.77) | METKDRPRKAA1PRKAA2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |