SCHEMBL1459693

SCHEMBL1459693

O=C(NC1CN2CCC1CC2)c1ccc2ncccc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 5/20 1.00
CHRNA7 P36544 9/20 0.83
HTR3E A5X5Y0 4/20 0.59
HTR3B O95264 4/20 0.59
HTR3D Q70Z44 4/20 0.59
HTR3C Q8WXA8 4/20 0.59
CYP2D6 P10635 1/20 0.59
CHRNB4 P30926 2/20 0.56
CHRNA3 P32297 2/20 0.56
ALOX15 P16050 1/20 0.56
TSHR P16473 1/20 0.56
PLK1 P53350 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1459284 1.00 HTR3A (1.00) HTR3ACHRNA7HTR3EHTR3BHTR3D
Hydrochloric Acid SCHEMBL4938323 0.99 HTR3A (0.98) HTR3ACHRNA7HTR3EHTR3BHTR3D
Hydrochloric Acid SCHEMBL4943294 0.99 HTR3A (0.98) HTR3ACHRNA7HTR3EHTR3BHTR3D
SCHEMBL6100751 0.94 HTR3A (0.89) HTR3ACHRNA7HTR3EHTR3BHTR3D
SCHEMBL1459330 0.91 CHRNA7 (1.00) HTR3ACHRNA7HTR3EHTR3BHTR3D
Hydrochloric Acid SCHEMBL4940947 0.90 CHRNA7 (1.00) HTR3ACHRNA7HTR3EHTR3BHTR3D
SCHEMBL6098306 0.85 HTR3A (0.74) HTR3ACHRNA7HTR3EHTR3BHTR3D
Hydrochloric Acid SCHEMBL6100277 0.84 HTR3A (0.72) HTR3ACHRNA7HTR3EHTR3BHTR3D
SCHEMBL6101169 0.83 HTR3A (0.71) HTR3ACHRNA7ALOX15PLK1
SCHEMBL5917821 0.83 CHRNA7 (0.71) HTR3ACHRNA7HTR3EHTR3BHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2025-02-04 US disclosed
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2022-10-06 US disclosed
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2022-06-14 US disclosed
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2021-11-04 US disclosed
US-20200108035-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2020-04-09 US disclosed
US-20190040057-A1 HETEROARYL CARBOXAMIDES BAYER HEALTHCARE AG (DE) 2019-02-07 US disclosed
US-9926311-B2 Heteroaryl carboxamides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-03-27 US disclosed
US-20180037957-A1 BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2018-02-08 US disclosed
EP-2931315-B1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2017-11-29 EP disclosed
US-9828642-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2017-11-28 US disclosed
US-20120172346-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG 2012-07-05 US disclosed
WO-2011036167-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2011-03-31 WO disclosed
US-20080009624-A1 Heteroaryl carboxamides BAYER HEALTHCARE AG (DE) 2008-01-10 US disclosed
US-20080009624-A1 Heteroaryl carboxamides BAYER HEALTHCARE AG (DE) 2008-01-10 US disclosed
EP-1448530-B1 HETEROARYL CARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2007-10-03 EP disclosed
EP-1448530-B1 HETEROARYL CARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2007-10-03 EP disclosed
US-7256288-B2 Heteroaryl carboxylic acid amides BAYER HEALTHCARE AG (DE) 2007-08-14 US disclosed
US-7256288-B2 Heteroaryl carboxylic acid amides BAYER HEALTHCARE AG (DE) 2007-08-14 US disclosed
EP-1448530-A1 HETEROARYL CARBOXYLIC ACID AMIDES Bayer HealthCare AG (DE) 2004-08-25 EP disclosed
WO-2003043991-A1 HETEROARYL CARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2003-05-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180037957-A1 BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT CHRNA7, CHRNA4, CHRNA5 HTR3A 112/4885CHRNA7 1/4885HTR3E 177/4885
US-20190040057-A1 HETEROARYL CARBOXAMIDES CNR2, GRIN2A, CNR1 HTR3A 194/4885CHRNA7 52/4885HTR3E 252/4885
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 HTR3A 131/4885CHRNA7 1/4885HTR3E 200/4885
US-20120172346-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 HTR3A 151/4885CHRNA7 1/4885HTR3E 416/4885
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT CHRNA7, CHRNA4, CHRNA5 HTR3A 131/4885CHRNA7 1/4885HTR3E 200/4885
US-20200108035-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 HTR3A 151/4885CHRNA7 1/4885HTR3E 416/4885
US-20080009624-A1 Heteroaryl carboxamides GRIN2A, GRIN2C, CNR2 HTR3A 318/4885CHRNA7 41/4885HTR3E 322/4885
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 HTR3A 112/4885CHRNA7 1/4885HTR3E 177/4885
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 HTR3A 151/4885CHRNA7 1/4885HTR3E 416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.