Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.54 |
| ▸ | KIT | P10721 | 3/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.54 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.44 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966763 | 0.88 | ENPP1 (0.71) | PDGFRBKITPDGFRAFLT3ENPP1 | |
| SCHEMBL4972356 | 0.86 | PDGFRB (0.66) | PDGFRBKITPDGFRAFLT3ENPP1 | |
| SCHEMBL14599467 | 0.86 | KIT (0.58) | PDGFRBKITPDGFRAFLT3NCF1 | |
| SCHEMBL22300094 | 0.77 | NCF1 (0.59) | PDGFRBENPP1NCF1HTR1AHTR7 | |
| SCHEMBL22291005 | 0.77 | NCF1 (0.67) | PDGFRBENPP1NCF1FGFR2HTR1A | |
| SCHEMBL17729157 | 0.76 | CHRM4 (0.48) | — | |
| SCHEMBL5528019 | 0.75 | PDGFRB (0.69) | PDGFRBKITPDGFRAFLT3ENPP1 | |
| SCHEMBL4969179 | 0.75 | PDGFRB (0.69) | PDGFRBKITPDGFRAFLT3ENPP1 | |
| SCHEMBL30446792 | 0.75 | NCF1 (0.65) | PDGFRBENPP1NCF1HTR1AHTR7 | |
| SCHEMBL4966832 | 0.75 | PDGFRB (0.71) | PDGFRBKITPDGFRAFLT3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | FLT3, BMX, ABL1 | PDGFRB 51/4885KIT 104/4885PDGFRA 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.