SCHEMBL14599680

SCHEMBL14599680

Ic1c2nc(c(-c3ccccc3)c3ccc(s3)c(I)c3nc(c(-c4ccccc4)c4ccc1[nH]4)C=C3)C=C2

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.44
▸ STAT1 P42224 1/20 0.44
▸ TOP1 P11387 4/20 0.44
▸ CYCS P99999 3/20 0.43
▸ TERT O14746 4/20 0.42
▸ ENPP2 Q13822 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14629723 0.87 STAT3 (0.36) STAT3STAT1TOP1CYCSTERT
SCHEMBL14629730 0.87 MAPT (0.40) TOP1CYCS
SCHEMBL14599687 0.85 TOP1 (0.39) TOP1CYCSTERTENPP2
SCHEMBL18510108 0.82 STAT3 (0.46) STAT3STAT1TOP1CYCSTERT
SCHEMBL30363117 0.80 TOP1 (0.62) STAT3STAT1TOP1CYCSTERT
SCHEMBL14599688 0.79 TOP1 (0.33) TOP1CYCSTERTENPP2
Hydrochloric Acid SCHEMBL30306704 0.79 TOP1 (0.60) STAT3STAT1TOP1CYCSTERT
Hydrochloric Acid SCHEMBL599425 0.79 TOP1 (0.60) STAT3STAT1TOP1CYCSTERT
SCHEMBL14629734 0.79 STAT3 (0.43) STAT3STAT1TOP1CYCSTERT
SCHEMBL29405434 0.78 TOP1 (0.64) STAT3STAT1TOP1CYCSTERT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070015742-A1 Porphyrin derivatives YAHIOGLU GOKHAN 2007-01-18 — — US disclosed
US-20070015742-A1 Porphyrin derivatives YAHIOGLU GOKHAN 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015742-A1 Porphyrin derivatives SCO2, CBR3, CBR1 STAT3 2315/4885STAT1 3081/4885TOP1 3538/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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