Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299970 | 0.84 | KMT2A (0.62) | KMT2AHTTL3MBTL1LMNAMAPT | |
| SCHEMBL6115772 | 0.84 | KMT2A (0.59) | KMT2AHTTL3MBTL1LMNAMAPT | |
| SCHEMBL6116412 | 0.82 | NPC1 (0.61) | KMT2AHTTL3MBTL1LMNAMAPT | |
| SCHEMBL1178416 | 0.81 | KMT2A (0.55) | KMT2AHTTL3MBTL1LMNAMAPT | |
| SCHEMBL1178424 | 0.81 | KMT2A (0.55) | KMT2AHTTL3MBTL1LMNAMAPT | |
| SCHEMBL1177620 | 0.81 | KMT2A (0.55) | KMT2AHTTL3MBTL1LMNAMAPT | |
| SCHEMBL7605713 | 0.81 | KMT2A (0.55) | KMT2AHTTL3MBTL1LMNAMAPT | |
| SCHEMBL17221629 | 0.81 | KMT2A (0.62) | KMT2AHTTL3MBTL1LMNAMAPT | |
| SCHEMBL19501371 | 0.81 | MAPT (0.50) | KMT2AHTTLMNAMAPTALDH1A1 | |
| SCHEMBL8481152 | 0.80 | POLB (0.67) | KMT2AHTTL3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166603-B2 | Dihydropyrimidone inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB CO. (US) | 2007-01-23 | — | — | US | disclosed |
| US-7166603-B2 | Dihydropyrimidone inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB CO. (US) | 2007-01-23 | — | — | US | disclosed |